Kev sib xyaw ua ke ntawm resveratrol thiab piperine yog txoj hauv kev qub
Kev sib xyaw ua ke ntawm resveratrol thiab piperine yog txoj hauv kev qub
Kev sib xyaw ua ke ntawm resveratrol thiab piperine tam sim no tau lees paub tias yog ib txoj hauv kev qub los txhim kho qhov kev noj qab haus huv ntawm resveratrol. Lub hauv paus tseem ceeb yog piperine inhibiting metabolic enzymes, qeeb metabolism, thiab txhawb kev nqus ntawm txoj hnyuv, yog li ntawd txo qhov kev poob sai ntawm resveratrol hauv lub cev.
Vim li cas resveratrol thiaj li yuav tsum tau ua kom muaj txiaj ntsig zoo dua?
Txawm hais tias resveratrol (feem ntau yog trans resveratrol) muaj peev xwm ua rau muaj kev tiv thaiv antioxidant, tiv thaiv kev o, tiv thaiv kab mob plawv, tiv thaiv kev laus, thiab lwm yam, nws qhov kev noj tau hauv qhov ncauj yog qis heev:
-Kev yaj dej tsis zoo: Cov rog yaj tau zoo, kev nqus plab qeeb.
-Kev hloov pauv thawj zaug muaj zog heev: tom qab noj, nws raug hloov pauv sai sai los ntawm glucuronidation thiab sulfation hauv txoj hnyuv thiab lub siab, thiab cov tshuaj prototype nkag mus rau hauv cov ntshav tsawg heev.
-Lub sijhawm luv luv: Thaum noj ib leeg xwb, cov tshuaj hauv cov ntshav yuav nce siab sai sai thiab txo qis sai sai.
Lub tshuab ua haujlwm ntawm piperine (3 lub luag haujlwm tseem ceeb)
Piperine (ib qho alkaloid nquag hauv kua txob dub / kua txob ntev) yog ib qho muaj zog bioavailability enhancer:
1. Tiv thaiv glucuronidation (qhov tseem ceeb tshaj plaws)
Tiv thaiv UDP glucuronosyltransferase (UGT) hauv daim siab thiab txoj hnyuv, thaiv txoj kev loj hlob ntawm resveratrol, txo cov cim ntawm cov metabolites tsis ua haujlwm, thiab ua kom ntev ntawm cov tshuaj prototype.
2. Tiv thaiv qhov efflux ntawm P-glycoprotein (P-gp)
Tiv thaiv cov tshuaj efflux twj tso kua mis ntawm txoj hnyuv epithelium, txo qhov pumping ntawm resveratrol mus rau hauv ileal lumen, thiab txhim kho kev nqus dej hauv lub cev.
3. Txhawb kev nqus ntawm txoj hnyuv thiab ncua kev zom zaub mov hauv plab
Hloov cov qauv me me ntawm cov hnyuv mucosa, ua kom cov ntshav ntws hauv zos ntau ntxiv, ua kom lub sijhawm nyob ntev dua, thiab txhim kho tus nqi nqus.
Cov pov thawj los ntawm kev tshawb nrhiav txog tsiaj txhu thiab tib neeg
1. Kev sim tsiaj (zoo heev)
-Nas: Resveratrol (100 mg/kg)+Piperine (10 mg/kg) - Qhov concentration siab tshaj plaws ntawm cov ntshav (Cmax) nce ntau dua 15 npaug
-Cheeb tsam nyob rau hauv lub sijhawm siv tshuaj (AUC, tag nrho kev raug tshuaj) nce ntxiv 229%
-Cov khoom tseem ceeb (resveratrol 3-O-glucuronic acid) AUC ↓ 81%
2. Kev tshawb fawb tib neeg (nrog rau qhov ntau npaum li cas thiab qhov sib txawv ntawm tus kheej)
-Ib feem ntawm kev tshawb fawb: * * 20 mg piperine + cov tshuaj resveratrol ntau (≥ 1 g) * * tuaj yeem ua rau cov tshuaj hauv cov ntshav ntau ntxiv thiab raug tshuaj ntau ntxiv.
-Qee qhov kev sim tshuaj kho mob (xws li 2.5 g resveratrol + 5/25 mg piperine) tsis tau ua tiav qhov tseem ceeb ntawm kev suav lej, qhia tias qhov sib piv ntawm cov tshuaj, poj niam txiv neej, thiab qhov sib txawv ntawm cov metabolism cuam tshuam rau qhov ua tau zoo.
-Kev Pom Zoo: Cov tshuaj piperine tsawg (5-20 mg) ua ke nrog resveratrol (100-500 mg) tseem muaj cov txiaj ntsig synergistic meej hauv tib neeg lub cev.
Cov lus qhia txog kev siv tshuaj thiab cov qauv piv txwv
1. Cov piv sib piv (feem ntau siv hauv kev ua lag luam thiab kev tshawb fawb)
-Resveratrol: Piperine = kwv yees li 50: 1 txog 20: 1
-Piv txwv li: - Resveratrol 100-200 mg + Piperine 5-10 mg
-Resveratrol 500 mg + Piperine 10-20 mg
2. Cov ntsiab lus tseem ceeb rau kev noj
-Noj nrog pluas noj/nrog cov rog zoo (xws li txiv ntoo qhuav, roj txiv roj) kom pab nqus tau zoo dua.
-Tsis txhob siv ua ke nrog cov tshuaj uas ua rau muaj zog UGT xws li rifampicin thiab phenytoin kom txo qhov ua tau zoo.
-Yuav tsum ceev faj thaum siv cov tshuaj anticoagulants (warfarin, aspirin) ua ke: nws yuav ua rau cov nyhuv antiplatelet ntau ntxiv thiab ua rau muaj kev pheej hmoo ntawm kev los ntshav.
Kev Txheeb Xyuas
-Cov tsiaj txhu: Piperine tuaj yeem ua rau kom muaj bioavailability ntawm resveratrol ntau zaus.
-Lub cev tib neeg: Cov tshuaj piperine tsawg (5-20 mg) tuaj yeem txhim kho kev nqus thiab ua rau cov tshuaj hauv cov ntshav ntau ntxiv.
-Mechanism: Tiv thaiv glucuronidation, suppresses P-gp efflux, thiab txhawb kev nqus ntawm txoj hnyuv.
-Daim ntawv thov: Kev sib xyaw ua ke ntawm cov tshuaj resveratrol, tiv thaiv kev laus, kab mob plawv, thiab cov tshuaj tiv thaiv kev o
Andy Biotech tau tsim thiab xa tawm cov hmoov cog qoob loo txij li xyoo 2012 thiab tau txais xoom cov khoom sib xyaw los ntawm txhua tus neeg siv khoom. Kev zoo yog qhov tseem ceeb tshaj plaws uas peb tsom mus rau. Yog xav paub ntxiv, thov hu rau sales@andybiotech.com